Dr. Orsolya Ivett Hoffmann - MATE Research
Overview
Hoffmann Orsolya Ivett is a senior research fellow and group leader at the Institute of Genetics and Biotechnology, Hungarian University of Agriculture and Life Sciences (MATE), where she leads the Model Animal Genetics Group.
Her research focuses on transgenesis, precision genome editing, and molecular biological methods to generate and characterize transgenic models, especially in rodents and rabbits. She pioneered the application of transposon-based transgenesis protocols in mammalian systems and has designed and executed studies creating and characterizing transgenic lines with tissue-specific gene expression.
In recent years, her research has increasingly focused on bioinformatics and computational genomics. She applies large-scale sequence analysis, comparative genomics, and database-driven approaches to investigate mitochondrial genome plasticity, nuclear mitochondrial DNA segments (NUMTs), and genome evolution across mammalian species. Her work integrates wet-lab molecular biology with in silico analysis pipelines, contributing to the development and curation of genomic databases and improving the interpretation of high-throughput sequencing data.
Research keywords:
Publications
Biró, B., Gál, Z., Fekete, Z., Klecska, E., & Hoffmann, O. I. (2024). Mitochondrial genome plasticity of mammalian species. BMC Genomics, 25(1), 278. DOI: 10.1186/s12864-024-10201-9
Biró, B., Gál, Z., Nagy, Z., Garcia, J. F., Batbold, T.-A., & Hoffmann, O. I. (2025). MANUDB: database and application to retrieve and visualize mammalian NUMTs. DATABASE: The Journal of Biological Databases and Curation. DOI: 10.1093/database/baaf009
Bókony, Veronika; Kalina, Csenge ; Ujhegyi, Nikolett ; Mikó, Zsanett ; Lefler, Kinga Katalin ; Vili, Nóra ; Gál, Zoltán ; Gabor, Caitlin R.; Hoffmann, Orsolya Ivett, Does stress make males? An experiment on the role of glucocorticoids in anuran sex reversal, JOURNAL OF EXPERIMENTAL ZOOLOGY PART A: ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY 341 : 2 pp. 172-181. , 10 p. (2024) DOI: 10.1002/jez.2772
Biró, Bálint ; Gál, Zoltán ; Schiavo, Giuseppina ; Ribari, Anisa ; Joe Utzeri, Valerio ; Brookman, Michael ; Fontanesi, Luca ; Ivett Hoffmann, Orsolya, Nuclear mitochondrial DNA sequences in the rabbit genome, MITOCHONDRION 66 pp. 1-6. , 6 p. (2022) DOI: 10.1016/j.mito.2022.07.003
Schiavo, Giuseppina ; Hoffmann, Orsolya Ivett* ; Ribani, Anisa ; Utzeri, Valerio Joe ; Ghionda, Marco Ciro ; Bertolini, Francesca ; Geraci, Claudia ; Bovo, Samuele ; Fontanesi, Luca, A genomic landscape of mitochondrial DNA insertions in the pig nuclear genome provides evolutionary signatures of interspecies admixture, DNA RESEARCH 24 : 5 pp. 487-498. , 12 p. (2017), DOI: 10.1093/dnares/dsx019
Katter, K., Geurts, A. M., Hoffmann, O., Mátés, L., Landa, V., Hiripi, L., … Izsvák, Z. (2013). Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits. FASEB Journal 27(3):930-941. DOI: 10.1096/fj.12-205526
Germline transgenesis in rabbits by pronuclear microinjection of Sleeping Beauty transposons. Nature Protocols, 9(4), 794–809. DOI: 10.1038/nprot.2014.009
Projects
